We are currently recruiting for the following active studies:
- BBRF - Mitochondrial Dysfunction, Reward And Dopamine In Bipolar Disorder: A Novel Approach Using Mitochondrial Complex I Imaging
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Dr. Phillips will examine mitochondrial Complex I (MC-I) in the brain in individuals with bipolar disorder (BD), and determine relationships among MC-I and indices of neural activity and neurotransmission known to be aberrant in BD. The study will guide future, larger-scale studies examining MC-I in BD to aid BD risk detection and the development of new, mitochondrial dysfunction-informed treatments.
- CENTRIM-BD - Elucidating Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder
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The purpose of this research study is to find out how a ketogenic diet influences brain structure and function in adults with bipolar disorder. The findings may help increase knowledge of and find better ways to diagnose and treat psychiatric disorders in the future.
Learn More on Pitt+Me - DIAMOND 3 - Reward, Impulsive Sensation Seeking and Emotion Dysregulation: Neural Mechanisms Underlying Risk for Bipolar Disorder in Young Adults
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This is a NIMH-funded renewal of our original Diamond study in which we aim to better identify bipolar spectrum disorders (BPSD) in at-risk young adults, and provide neural targets for novel (e.g., neuromodulation) interventions to delay or prevent, BPSD.
Learn More on Pitt+Me: Adults without Family History of Mood Disorders
Learn More on Pitt+Me: Adults with Family History of Bipolar Disorder
Learn More on Pitt+Me: Adults with Family History of Depression
- ENCORE 2 - Linking OCD-like Behaviors with Abnormalities in the OCD Neural Network
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The purpose of this research study is to examine changes in brain activity in participants with and without Obsessive Compulsive Disorder (OCD).
- MULTIMODAL - Linking mania/hypomania with abnormal reward expectancy- and approach-related neural network activity and dopamine release
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This research study will examine how medication affects the brain in young adults with Bipolar Disorder and healthy controls without Bipolar Disorder.
Learn More on PItt+Me: Healthy Controls
Learn More on Pitt+Me: Non-Bipolar
Learn More on Pitt+Me: Bipolar
- PEAR - Moving beyond the pain-suicidality link: An Investigation of Fluctuations in Social Threat and Neural Response to Social Threat in Momentary Pain and Proximal Risk for Suicidal Ideation in adolescence
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The main purpose of the PEAR study is to help researchers better understand why some teens who have physical pain in their body go on to develop depressive symptoms or suicidal thoughts, while other teens do not. Given that research suggests that some brain regions are involved in both physical pain and mood, one of the aims of this study is to understand how daily life experiences, such as social interactions, and the brain may be related to daily changes in both physical pain and mood. We would like to also better understand how daily social experiences, the brain, pain and mood, may work together to influence the development of depressive symptoms or suicidal thoughts for some teens. Ultimately, we hope this information will help us learn how to improve emotional health in teens.
Learn More on Pitt+Me: Teens 14-17 years old
Learn More on Pitt+Me: Parent of Teen 14-17 years old
Lean More on Pitt+Me: 18-year-olds
- MATRIX - Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorder
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This is a proof-of-concept study and a promising way forward to develop new device-based interventions for individuals with Cocaine Use Disorder.
*Coming Soon*